The demand for proteomic analysis and transcriptome analysis is increasing in recent times. Proteomic helps in the study of proteins, which form a vital component in the living organisms. While there are several applications of proteomics, some of the most important ones are listed below.
1. Post-translation Modification
Proteomics includes several unique features that help in effectively analyzing the post-translation modifications of the different proteins. Whether it is a sulphation, phosphorylation, or glycosylation modification, proteomics helps in studying them all. In comparison to protein identification, determining protein modification is much more difficult. However, understanding the modifications is vital as they are vital for solubility, localization, and activity of the proteins within the cells. With the use of proteomics analysis, determining protein translation becomes easy.
2. Guide to Drug Development
Proteomics also find wide application in the development of different drugs. As diseases, as well as treatments, manifest at the level of the proteins, proteomics plays an important role in drug development. After drug application, the proteins’ pattern usually changes and provides useful information related to the action mechanism.
It helps in finding the toxicological effects and therapeutic effects of the different drugs. The application of proteomic analysis in the drug industry involves identification of the efficacy of the biomarker, target identification as well as validation, and investigation about drug toxicity or actions.
It also helps in discovering antimalarial drugs that can effectively target the purine binding proteins. Moreover, advancements in the field of proteomics enable the development of personalized medications for ensuring better health outcomes and fewer side effects.
3. Guide to Protein-Protein Interaction
Another significant application of proteomic analysis is to study protein-protein interaction. It helps in providing you with a better understanding of cell biology. It provides detailed insights about the time of expression of the proteins, the expression levels, and the interaction with other proteins. All these information forms an intermediate for a particular biological function’s performance. It also proves to be useful for therapeutic purposes.
There are several methods available to study protein-protein interactions. Some of the popular techniques include the yeast two-hybrid system, phage display, yeast hybrid system, and the application of fluorescence resonance energy transfer (FRET). Localization of the cell proteins is becoming a popular proteomics strategy in recent times that offers a better understanding of the protein functions in the cellular networks that are complex in nature.
4. Guide to Molecular Medicine
Through proteomics, certain valuable information can be obtained that helps in designing medicines. Proteomics help in discovering the relevance of the protein to the medical field. Owing to the connection between proteins, genes, and diseases, proteomics technology proves to be helpful in the discovery of various molecular medicines. Through the study of the defective proteins that causes specific diseases, it becomes easy to develop molecular medicines by analyzing the findings.
5. Guide to Protein Expression Profiling
Proteomics analysis also plays an important role in protein expression profiling. It is considered the most prominent application of proteomic. It helps in measuring as well as analyzing the protein expression levels of the different protein samples. It helps in the identification of the disease-specific proteins as well as the signalling mechanisms.
Proteomic can even aid in the identification of the cancerous cells owing to the difference in protein expressions between cancer and non-cancerous cells. It also helps in analyzing the genomic protein sets. Proteomic offers a promising transformation in the domain of biochemical analysis.
Apart from the applications mentioned above, there are various other uses of proteomics. Proteomics is widely being used for the determination of functional protein networks. The advancements in the field of protein, as well as transcriptome analysis, will help in increasing the number of applications even more in the coming years. Proteomics is especially growing to be a leading area for the identification as well as characterization of the different cellular gene products or proteins.